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Craniofacial Anomalies | Symptoms & Causes

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An analysis of the FGFR2 mutations that cause bent bone dysplasia revealed a nucleolar role for FGFR2 in promoting osteoprogenitor differentiation while decreasing proliferation, providing an alternative mechanism for alterations in this balance Deletions within this region affect growth of the medionasal process through downregulation of Myc , and misexpression of genes involved in ribosome assembly and translation For Permissions, please email: Disorders of Pharyngeal Arches 1 and 2 Facial dysostoses The recent identification of mutation of multiple spliceosome components in facial dysostoses, suggests a shared underlying sensitivity of PA development with the ribosomopathies see above. Cell , 33 , 56—

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